Background::Thyroid dysfunction is associated with cardiovascular diseases. However, the role of thyroid function in lipid metabolism remains partly unknown. The present study aimed to investigate the causal association between thyroid function and serum lipid metabolism via a genetic analysis termed Mendelian randomization (MR).Methods::The MR approach uses a genetic variant as the instrumental variable in epidemiological studies to mimic a randomized controlled trial. A two-sample MR was performed to assess the causal association, using summary statistics from the Atrial Fibrillation Genetics Consortium ( n = 537,409) and the Global Lipids Genetics Consortium ( n = 188,577). The clinical measures of thyroid function include thyrotropin (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) levels, FT3:FT4 ratio and concentration of thyroid peroxidase antibodies (TPOAb). The serum lipid metabolism traits include total cholesterol (TC) and triglycerides, high-density lipoprotein, and low-dens

作者：Wang Jing-Jia；Zhuang Zhen-Huang；Shao Chun-Li；Yu Can-Qing；Wang Wen-Yao；Zhang Kuo；Meng Xiang-Bin；Gao Jun；Tian Jian；Zheng Ji-Lin；Huang Tao；Tang Yi-Da

来源：中华医学杂志英文版 2021 年 134卷 9期