Background::The neoadjuvant chemotherapy is increasingly used in advanced gastric cancer, but the effects on safety and survival are still controversial. The objective of this meta-analysis was to compare the overall survival and short-term surgical outcomes between neoadjuvant chemotherapy followed by surgery (NACS) and surgery alone (SA) for locally advanced gastric cancer.Methods::Databases (PubMed, Embase, Web of Science, Cochrane Library, and Google Scholar) were explored for relative studies from January 2000 to January 2021. The quality of randomized controlled trials and cohort studies was evaluated using the modified Jadad scoring system and the Newcastle-Ottawa scale, respectively. The Review Manager software (version 5.3) was used to perform this meta-analysis. The overall survival was evaluated as the primary outcome, while perioperative indicators and post-operative complications were evaluated as the secondary outcomes.Results::Twenty studies, including 1420 NACS cases and 1942 SA cases, were en

作者：Yu Jian-Hong；Wang Zao-Zao；Fan Ying-Chong；Liu Mao-Xing；Xu Kai；Zhang Nan；Yao Zhen-Dan；Yang Hong；Zhang Cheng-Hai；Xing Jia-Di；Cui Ming；Su Xiang-Qian

来源：中华医学杂志英文版 2021 年 134卷 14期