Background::Type 2 diabetes mellitus (T2DM) is an independent risk factor for colorectal cancer (CRC), and the patients with CRC and T2DM have worse survival. The human gut microbiota (GM) is linked to the development of CRC and T2DM, respectively. However, the GM characteristics in patients with CRC and T2DM remain unclear.Methods::We performed fecal metagenomic and targeted metabolomics studies on 36 samples from CRC patients with T2DM (DCRC group, n = 12), CRC patients without diabetes (CRC group, n = 12), and healthy controls (Health group, n = 12). We analyzed the fecal microbiomes, characterized the composition and function based on the metagenomics of DCRC patients, and detected the short-chain fatty acids (SCFAs) and bile acids (BAs) levels in all fecal samples. Finally, we performed a correlation analysis of the differential bacteria and metabolites between different groups. Results::Compared with the CRC group, LefSe analysis showed that there is a specific GM community in

作者：Yang Yong；Han Zihan；Gao Zhaoya；Chen Jiajia；Song Can；Xu Jingxuan；Wang Hanyang；Huang An；Shi Jingyi；Gu Jin

来源：中华医学杂志英文版 2023 年 136卷 23期