The effects of tea polyphenols (TP) on mitochondrial lipid peroxidation, blood brain barrier (BBB) permeability, mitochondrial adenosine triphosphatase (ATPase) activity and adenosine triphosphate (ATP) content in cerebral cortices of rats underwent repeated +10 G z exposures were observed in this experiment. The results showed that TP had significantly inhibitive effect on mitochondrial malondialdehyde (MDA) formation in brains of rats underwent +G z exposures, but no significant effects on superoxide dismutase (SOD) and selenium dependent glutathione peroxidase (SeGSHpx) activities. TP had remarkable protective effect on +G z induced BBB injury, as indicated by measuring the leakage of Evan's blue. In addition, TP could substantially increase mitochondrial ATPase activity and ATP content in cerebral cortices of rats. These results suggested that natural antioxidant TP had protective effect on +G z induced brain injury in rats.

作者：Zhan Hao；Xin Yimei；Tang Guixiang；Liu Renfu

来源： 1995 年 06卷 2期