[Summary] Non-steroidal anti-inflammatory drugs ( NSAIDs) are a broad class of non glucocorticoid drugs which are extensively used in anti-inflammatory, analgesic, and antipyretic therapies.However, NSAIDs may cause many side effects , most commonly in gastrointestinal ( GI) tract.Cardiovascular system , kidney, liver, central nervous system and hematopoietic system are also involved.NSAID-induced GI side effects not only endanger the patients′health, increase mortality, but also greatly increase the cost of medical care.Therefore, how to reduce GI side effects is of particular concern to clinicians.The Chinese Rheumatism Data Center ( CRDC ) and Chinese Systemic Lupus Erythematosus Treatment and Research Group ( CSTAR ) compose a “Recommendation for the prevention and treatment of non-steroidal anti-inflammatory drug-induced gastrointestinal ulcers and its complications”, as following: ( 1 ) GI lesions are the most common side effects of NSAIDs.(2) NSAID-induced GI side effects include gastritis , esoph

作者：[1]国家风湿病数据中心；[2]中国系统性红斑狼疮研究协作组

来源：中华内科杂志 2017 年 56卷 1期