Sepsis and septic shock as a result of an invasire infection are challenging problems in extensively burned patients, and frequently end in multiple organ dysfunction syndrome (MODS).It is of great significance to further elucidate the pathogenetic mechanisms, and to seek novel intervention strategies to prevent and treat sepsis/MODS secondary to severe bums. A more complete understanding of the pathogenetic mechanisms of postburn sepsis would certainly elicit a number of potential therapeutic strategies for it. It is our belief that compre hensive clinical measures for management of severe sepsis should include rapid, adequate fluid resuscitation for bum shock, early feeding, effective control of infection, early escharectomy, and reinforcement of organ support. Once bum wound sepsis occurs, prompt removal of infected necrotic tissue is the key procedure to ensure a successful result. Further study is necessary to determine the precise mechanisms of these protective effects and the clinical advantages for

作者：姚咏明；盛志勇；柴家科

来源：中华烧伤杂志 2008 年 24卷 5期