Scar,either hypertrophic scar or keloid,is one of the most common complications due to proliferative disorder of fibrosis in the process of wound healing after burn injuries,trauma,and surgical operations.To repair the cosmetic and functional impairments caused by scars poses a great challenge to all the burn surgery workers.With the advances in both basic research and clinical treatment,the understanding of scar formation and the therapeutic strategies of scar have been improved significantly.However,the remaining problems are still outstanding.In this discussion,the advances and problems in the scientific research in this field,including genetic predisposition,candidate gene,dysfunction of fibroblasts,interaction between fibroblasts and keratinocytes,as well as animal models for hypertrophic scar and keloid were summarized.In addition,the progreses in the clinical therapies are also discussed,including pressure treatment,silicone gel sheeting,corticosteroids,laser,and other emerging treatment strategies.T

作者：胡大海；刘佳琦

来源：中华烧伤杂志 2011 年 27卷 6期