Inflammasomes are large muhi-protein complexes that serve as a platform for caspase-1 activation,and this process induces subsequent maturation and secretion of the proinflammatory cytokines IL-1β and IL-18,as well as pyroptosis.As an important component of the innate immune system,early activation of inflammasomes in a variety of immune cell subsets can mediate inflammatory response and immunological conditions after burn injury.Here,we review the current knowledge of inflammasomes and its role in immunological and inflammatory response at the early stage of burn injury.
作者:张放;郦佳慧;夏照帆
来源:中华烧伤杂志 2014 年 30卷 3期