Background and purpose:Carbon monoxide (CO) is a gas product of combustion, considered highly poisonous. Prolonged CO exposure is responsible for more than half of fatal poisonings and is also one of the leading causes of poisoning in Western countries. We aimed to compare the effectiveness of therapy with hyperbaric oxygen (HBO) versus normobaric oxygen (NBO) in the setting of carbon monoxide poisoning (COP).Methods:We independently searched the National Library of Medicine′s Medline (PubMed?), ScienceDirect?，and Scielo? for any relevant studies published from 1989 to 2017, using the following keywords: hyperbaric therapy, hyperbaric oxygenation, normobaric therapy, carbon monoxide poisoning, carboxyhemoglobin, Haldane effect. We analyzed the studies that suggested the effectiveness of HBO or NBO. Also，we searched for studies related to COP; including history，epidemiology (risk factors，incidence，demographics)，pathophysiology, clinical manifestations, diagnosis, and treatment.Results:Sixty-eight articl

来源：中华物理医学与康复杂志 2022 年 44卷 6期