Ammonia is a toxin that has been strongly implicated in the pathogenesis of hepatic encephalopathy (HE), and astrocytes appear to be the principal target of ammonia toxicity. Glutamine, a...
来源：《Neurochemistry International》 2003 年 43卷 4/5 期
Acute intoxication with large doses of ammonia leads to rapid death. The main mechanism for ammonia elimination in brain is its reaction with glutamate to form glutamine. This reaction is...
来源：《Neurochemistry International》 2003 年 43卷 4/5 期
Hyperhomocysteinemia is a risk factor in neurodegeneration. It has been suggested that apart from disturbances in methylation processes, the mechanisms of this effect may include excitoto...
来源：《Neurochemistry International》 2003 年 43卷 4/5 期
Mouse GABA transporters belong to the family of Na(+) and Cl(-) dependent neurotransmitter transporter. GABA transport, by these family members, was shown to be electrogenic and driven by...
来源：《Neurochemistry International》 2003 年 43卷 4/5 期
Release of preloaded [3H]D-aspartate in response to depolarization induced by N-methyl-D-aspartate (NMDA) or the endogenous agonist glutamate was characterized using cultured glutamatergi...
来源：《Neurochemistry International》 2003 年 43卷 4/5 期
Besides its neurotrophic and neuroprotective effects on dopaminergic neurons and spinal motoneurons, glial cell line-derived neurotrophic factor (GDNF) has potent neuroprotective effects ...
来源：《Neurochemistry International》 2003 年 43卷 4/5 期
The alpha-ketoisocaproic acid (KIC) is a short branched-chain monocarboxylate, which accumulates in neural cells. It plays an important role in maintaining nitrogen balance in the brain, ...
来源：《Neurochemistry International》 2003 年 43卷 4/5 期
Ischemia limits the delivery of oxygen and glucose to cells and disturbs the maintenance of mitochondrial membrane potential (MMP). MMP regulates the production of high-energy phosphate a...
来源：《Neurochemistry International》 2003 年 43卷 3 期
Several cerebrovascular alterations have been described in Alzheimer's disease (AD) including an accumulation of beta-amyloid (betaA) on the vascular walls in the brain. To investigate th...
来源：《Neurochemistry International》 2003 年 43卷 3 期
Evidence from both epidemiological and experimental observations have fueled the belief that the high consumption of fruits and vegetables rich in carotenoids may help prevent cancer and ...
来源：《Mutation Research》 2003 年 543卷 3 期
