Patients with end-stage renal disease die from cardiovascular disease at a much younger age than people in the general population do. Here, we review the evidence linking early renal insufficiency (ERI) to an increased cardiovascular risk. A number of cardiovascular risk factors become prevalent with ERI, including night-time hypertension, increase in serum levels of lipoprotein (a), homocysteine and asymmetric dimethyl-arginine, and insulin resistance. Also, an epidemiologic association between coronary artery disease (CAD) and nephrosclerosis, a frequent cause of ERI in the elderly, is documented. In the middle-aged, general population ERI, found in 8

作者：Johannes F E, Mann；Hertzel C, Gerstein；Janice, Pogue；Eva, Lonn；Salim, Yusuf

来源：American journal of cardiovascular drugs : drugs, devices, and other interventions 2002 年 2卷 3期