Background. Radiation-induced sarcomas are well-known potential late sequelae of radiation therapy. They are of rare occurrence in jaw bones and are even rarer in the maxilla. Case report. We report a case of radiation-induced osteosarcoma involving the maxilla in a patient treated with radiotherapy for nasopharyngeal carcinoma 14 years ago. Despite neoadjuvant chemotherapy, surgical treatment could not be performed, and the patient received palliative chemotherapy. Conclusions. Radiation-induced osteosarcomas are aggressive and often elude early detection and timely intervention, rapidly leading to early demise of afflicted patients. Long-term patient follow-up and a high index of suspicion are crucial for timely intervention.

作者：Imene, Chabchoub；Olfa, Gharbi；Sami, Remadi；Sami, Limem；Amel, Trabelsi；Makrem, Hochlef；Leila, Ben Fatma；Amel, Landolsi；Moncef, Mokni；Chekib, Kraiem；Slim, Ben Ahmed

来源：Journal of oncology 2009 年 2009卷