Twenty-one hepatitis B virus (HBV) isolates from the state of Haryana (North India) were studied for genotype, subgenotype, serotype distribution and precore mutations. Assays of alanine aminotransminase (ALT) and HBeAg were performed on all samples. Genotypes, subgenotypes and serotypes were determined by amplification of pre-S1/S2 regions followed by RFLP and also by phylogenetic analysis of amplified products. Mutations were studied by amplification and sequencing of the precore region. Twenty-four percent of the samples had high ALT levels and 90

作者：Jasbir, Singh；Caroline, Dickens；Vikas, Pahal；Rajesh, Kumar；Rajender, Chaudhary；Anna, Kramvis；Michael C, Kew

来源：Intervirology 2009 年 52卷 5期