Coronary artery occlusion is associated with the risk of ventricular remodelling, heart failure, and cardiogenic shock. Novel strategies are sought to treat these ominous complications. We examined the effect of a pericardial-derived fat flap secured over an acute infarct caused by coronary occlusion.A novel intervention consisting of the pericardial isolation of a vascularized adipose flap and its transposition fully covering acute infarcted myocardium was developed in the swine model of coronary artery ligation (n= 52). Left ventricular (LV) ejection fraction and LV end-diastolic and end-systolic volumes were assessed using magnetic resonance imaging (MRI). Infarct size and gene expression analysis were performed on Day 6 and 1 month. Histological changes, collagen volume fraction (CVF), and vascular density were also evaluated on postmortem sections. One month after the intervention, a 18.8

作者：Carolina, Gálvez-Montón；Cristina, Prat-Vidal；Santiago, Roura；Jordi, Farré；Carolina, Soler-Botija；Aida, Llucià-Valldeperas；Idoia, Díaz-Güemes；Francisco M, Sánchez-Margallo；Alejandro, Arís；Antoni, Bayes-Genis

来源：Cardiovascular research 2011 年 91卷 4期