Creutzfeldt-Jakob disease is a rapidly progressive, fatal, transmissible neurodegenerative disorder caused by prion protein. It is still considered rare in countries like India. This is probably due to nonavailability of autopsy studies in majority of the center. The recent European diagnostic criterion for sporadic CJD (sCJD) is useful for making an early diagnosis.To report a series of patients of probable sCJD from a neurology institute of eastern India.Patients of rapidly developing dementia fulfilling the diagnostic criteria for sCJD were included. All were investigated in detail to find out any possible treatable cause including electroencephalography (EEG), magnetic resonance imaging (MRI) of brain, and cerebrospinal fluid analysis.A total 10 patients of probable sCJD diagnosed using the European diagnostic criterion between December 2011 and January 2013. The clinical features are consistent with other reported series. While 60

作者：Atanu, Biswas；Namrata, Khandelwal；Alak, Pandit；Arijit, Roy；Deb Sankar, Guin；Goutam, Gangopadhyay；Asit, Senapati

来源：Annals of Indian Academy of Neurology 2013 年 16卷 4期