There are currently no large cases series documenting poisoning with paracetamol modified-release (Panadol Osteo®, GlaxoSmithKline, Sydney, NSW, Australia). Management guidelines recommend at least two serum paracetamol concentrations 4 h apart and initiating treatment with N-acetylcysteine (NAC) if more than 10 g is ingested.To describe a cohort of Panadol Osteo® poisoning and determine if the management of identified cases was consistent with existing guidelines.Descriptive retrospective case series presenting to a metropolitan hospital network with paracetamol poisoning from October 2009 to September 2013.There were 42 cases of Panadol Osteo® poisoning identified. Twenty-nine patients (median ingested dose 19 950 mg) were treated with NAC, of which 27 were acute single ingestions. Of NAC-treated patients, 85

作者：Andis, Graudins

来源：Emergency medicine Australasia : EMA 2014 年 26卷 4期