The characteristics of AIDS is that HIV infection induces CD4　+ T cell defects that includes a quantitave CD4　+ T cells depletion and a loss of T helper cells function leading to a progressive immune deficiency. Early report indicated that this immune deficiency was irreversible, even with the antiretroviral therapies. More recently, however, clinical benifits of hightly active antiretroviral therapies (HAART) are increasingly evidenced by resolving opportunistic infections and malignancies, as well as declining hospitalization and mortality rates. This suggests that potent and sustained suppression of viral replication, at least to some extent, is associated with reconstitution of the immune system even in adult patients treated at advanced stages of the disease. Such immune reconstitution which was demonstrated firstly by a French reseach group includes (the group leader is Pr Brigitte Autran)(1) a rapid rise in CD4　+ and CD8+ T cells followed by a slower CD4　+ T cell increase; (2) a rapid rise in m

作者：李太生；Guislaine Carcelaine；Patrice Debre；Brigitte Autran

来源：基础医学与临床 2001 年 21卷 1期