Objective: To study the effects of raloxifene on the growth of the human ovarian cancer cell line Skov3 and on the expression of cell proliferative antigen Ki-67 in vitro.Methods: The proliferative capacity of the ovarian cancer cell line Skov3 in the culture medium with raloxifene was evaluated by the microculture tetrazolium assay (MTT) and the expression of cell proliferation was appraised by the immunohistochemical staining of ki-67.Results: The growth of ovarian cancer cell line Skov3 was inhibited by raloxifene at high concentrations, while a trend of growth promotion at initial then followed by growth inhibition was found when raloxifene was at low concentrations. Raloxifene at high concentrations not only significantly reduced the expression of Ki-67 but also destroyed the cell structure.Conclusion: Raloxifene does not stimulate the growth of human ovarian cancer cell line Skov3significantly.

来源：生殖医学杂志 2004 年 13卷 z1期