Spinal cord injury ( SCI ) leads to high rate of mortality. SCI consists of primary spinal cord injury and secondary spinal cord injury. The first step is primary mechanical damage that occurs within minutes as a result of mechanical SCI. The second step is the secondary injury triggered by the primary damage. Then it leads to apoptotic nerve cell death. Currently, the management of patients with acute spinal cord injury ( SCI ) includes pharmacological agents, surgical intervention and cellular therapies. Pharmacological agents includes steroids, including methylprednisolone, ganglioside GM-1, opioid receptor antagonists, thyrotropin releasing hormone and its analogs, nimodipine, gacyclidine ( GK11 ), magnesium, minocycline, cethrin , erythropoietin, estrogen, progesterone, cyclooxygenase inhibitors, riluzole, atorvastatin, and antioxidants. Recently, attempted cellular therapy and transplantations are promising. Cellular therapy consists of Schwann cell transplantation, olfactory ensheathing cells transpl

作者：孙祥耀；海涌

来源：中国骨与关节杂志 2016 年 5卷 6期