A possible role of IL-1RN gene polymorphism in the outcome of gastrointestinal diseases associated with H. pylori infection.-临床诊疗知识库

A possible role of IL-1RN gene polymorphism in the outcome of gastrointestinal diseases associated with H. pylori infection.

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作者：

Rejane, Mattar；Sergio Barbosa, Marques；Anibal Ferreira, Dos Santos；Maria, do Socorro Monteiro；Kiyoshi, Iriya；Flair José, Carrilho

来源：

Clinical and experimental gastroenterology 2013 年 6卷

标签：

Helicobacter pylori IL-1RN polymorphism gastric cancer peptic ulcer

To verify whether the variable number of tandem repeat (VNTR) polymorphism in the IL-1RN gene that encodes the interleukin (IL)-1 receptor antagonist (IL-1Ra) plays a role in the outcome of gastrointestinal diseases associated with Helicobacter pylori (H. pylori) infection.Patients with normal endoscopy (n = 71), inflammation of the upper gastrointestinal tract only (n = 196), gastric ulcer (n = 28), duodenal ulcer (n = 76), and gastric cancer (n = 19) were studied. H. pylori infection was diagnosed by the urease test, histological examination, and polymerase chain reaction. The IL-1 receptor antagonist gene (IL-1RN intron 2 VNTR) was analyzed by polymerase chain reaction. Gastritis was scored according to the updated Sydney system of classification.H. pylori infection was an independent risk factor for mild (odds ratio [OR] = 5.53 [95

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