Two recent genome-wide association studies in Asians have reported the association between the PSCA (prostate stem cell antigen) rs2294008C>T gene polymorphism and two Helicobacter pylori infection-related diseases such as gastric cancer (GC) and duodenal ulcer (DU). Since rs2294008 allele frequencies differ notably among ethnicities, we aimed to assess the role of rs2294008 on the susceptibility to GC and DU in a Caucasian population in Spain. Moreover, the relevance of rs2294008 on GC prognosis was evaluated. Genomic DNA from 603 Spanish patients with primary GC, 139 with DU and 675 healthy controls was typed for the PSCA rs2294008C>T polymorphism by PCR-TaqMan assays. H. pylori infection [odds ratio (OR): 8.27; 95

作者：María Asunción, García-González；Luis, Bujanda；Enrique, Quintero；Santos, Santolaria；Rafael, Benito；Mark, Strunk；Federico, Sope?a；Concha, Thomson；Angeles, Pérez-Aisa；David, Nicolás-Pérez；Elizabeth, Hijona；Patricia, Carrera-Lasfuentes；Elena, Piazuelo；Pilar, Jiménez；Jesús, Espinel；Rafael, Campo；Marisa, Manzano；Fernando, Geijo；María, Pellise；Manuel, Zaballa；Ferrán, González-Huix；Jorge, Espinós；Llúcia, Titó；Luis, Barranco；Roberto, Pazo-Cid；Angel, Lanas

来源：International journal of cancer 2015 年 137卷 6期