Biological activity of Helicobacter pylori oncoprotein CagA is determined by a diversity in the tyrosine phosphorylation motif sites. In the present study, the diversity and the type of the H. pylori CagA EPIYA motifs and their association with gastric ulcer (GU) and duodenal ulcer (DU) in Iranian dyspeptic patients were assessed. PCR amplification, sequencing, and bioinformatic analysis were performed to determine the pattern of CagA EPIYA motifs. Of 168 H. pylori cagA(+) strains, the frequency of ABC was 93.50
作者：Sahar, Honarmand-Jahromy；Farideh, Siavoshi；Reza, Malekzadeh；Taher Nejad, Sattari；Saeid, Latifi-Navid
来源：Microbial pathogenesis 2015 年 89卷
