Incident lacunes preferentially localize to the edge of white matter hyperintensities: insights into the pathophysiology of cerebral small vessel disease.-临床诊疗知识库

Incident lacunes preferentially localize to the edge of white matter hyperintensities: insights into the pathophysiology of cerebral small vessel disease.

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作者：

Marco, Duering；Endy, Csanadi；Benno, Gesierich；Eric, Jouvent；Dominique, Hervé；Stephan, Seiler；Boubakeur, Belaroussi；Stefan, Ropele；Reinhold, Schmidt；Hugues, Chabriat；Martin, Dichgans

来源：

Brain : a journal of neurology 2013 年 136卷 Pt 9期

标签：

cerebral small vessel disease lacunes pathomechanisms small vessel stroke white matter hyperintensities

White matter hyperintensities and lacunes are among the most frequent abnormalities on brain magnetic resonance imaging. They are commonly related to cerebral small vessel disease and associated with both stroke and dementia. We examined the spatial relationships between incident lacunes and white matter hyperintensities and related these findings to information on vascular anatomy to study possible mechanistic links between the two lesion types. Two hundred and seventy-six patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a genetically defined small vessel disease with mutations in the NOTCH3 gene were followed with magnetic resonance imaging over a total of 633 patient years. Using difference images and Jacobian maps from registered images we identified 104 incident lacunes. The majority (n = 95; 91.3

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