First trimester combined test for Down syndrome screening in unselected pregnancies - a report of a 13-year experience.-临床诊疗知识库

First trimester combined test for Down syndrome screening in unselected pregnancies - a report of a 13-year experience.

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作者：

Fa-Kung, Lee；Li-Ching, Chen；Mei-Leng, Cheong；Ching-Yu, Chou；Ming-Song, Tsai

来源：

Taiwanese journal of obstetrics & gynecology 2013 年 52卷 4期

标签：

Down syndrome screening combined test first trimester prenatal diagnosis

To analyze the performance of the first trimester Down syndrome screening in a single medical center in Northern Taiwan.From April 1999 to June 2012, a total of 25,104 pregnant women at gestational age of 10 weeks to 13 weeks 6 days received first trimester "combined test" for Down syndrome screening. The test combines the ultrasound scan of nuchal translucency thickness and maternal biochemical serum levels of pregnancy-associated plasma protein A (PAPP-A) and free beta-human chorionic gonadotropin (β-hCG). A positive screen was defined as an estimated Down syndrome risk ≥ 1/270, and either chorionic villous sampling or amniocentesis was performed for fetal chromosomal analyses.Seventy-eight of the 25,104 pregnancies were proven to have fetal chromosome anomalies. The detection rates for trisomy 21, trisomy 18, Turner syndrome, and other chromosome anomalies were 87.5

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