Serum pre-adipocyte factor-1 (pref-1) is an inhibitor of adipocyte differentiation that increases in small for gestational age fetuses. It plays a role in adipose metabolism and is associated with an increased risk of metabolic diseases in adulthood. We hypothesized that preadipocyte factor-1 (pref-1) concentration is altered in fetuses born to women with gestational diabetes mellitus (GDM).Umbilical cord blood pref-1 concentrations were determined by enzyme-linked immunosorbant assay in 37 fetuses from pregnancies complicated by GDM and 45 fetuses from normal pregnancies.Serum pref-1 concentrations were significantly lower in fetuses of women with GDM compared to normal pregnancies (16.12±6.48 vs. 22.09±7.22 μg/l, P=0.001). Birth weight was significantly higher in GDM fetuses compared to normal pregnancies (3567±544 vs. 3253±370 g, P=0.003).Pregnancies complicated by GDM have decreased fetal pref-1 concentrations compared to normal pregnancies. These differences may be significant in terms of their later development of metabolic conditions.

作者：Jie, Li；Qiuyuan, Zhu；Hanzhi, Wang；Cong, Han；Qunyan, Zhou；Hefeng, Huang；Minyue, Dong

来源：Clinica chimica acta; international journal of clinical chemistry 2014 年 431卷