Worsening heart failure (WHF) in the first 7 days after an admission for acute HF (AHF) has been proposed as a therapeutic target in several recent AHF studies and was a co-primary endpoint of the VERITAS studies.Patients were randomized within 24 h of admission for AHF. WHF was defined as worsening or persistent signs and symptoms of HF requiring additional intravenous or mechanical therapy for HF or death within 7 days of randomization. Multivariable models were developed to predict the time to WHF through day 7. Unadjusted and multivariable-adjusted associations of WHF with the length of stay (LOS) of the index hospitalization, and 30- and 90-day outcomes were estimated. WHF occurred by day 7 in 27

作者：Gad, Cotter；Marco, Metra；Beth A, Davison；Stefanie, Senger；Robert C, Bourge；John G F, Cleland；Guillaume, Jondeau；Henry, Krum；Christopher M, O'Connor；John D, Parker；Guillermo, Torre-Amione；Dirk J, van Veldhuisen；Olga, Milo；Isaac, Kobrin；Maurizio, Rainisio；John J V, McMurray；John R, Teerlink

来源：European journal of heart failure 2014 年 16卷 12期