These studies conducted analyses to examine patient characteristics and outcomes associated with worsening heart failure (WHF).WHF during an admission for acute heart failure (AHF) represents treatment failure and is a potential therapeutic target for clinical trials of AHF.Individual patient data from the PROTECT (Placebo-Controlled Randomized Study of the Selective A1 Adenosine Receptor Antagonist Rolofylline for Patients Hospitalized with Acute Decompensated Heart Failure and Volume Overload to Assess Treatment Effect on Congestion and Renal Function) and RELAX-AHF (Relaxin in Acute Heart Failure) phase II and III studies were pooled for analysis.Of 3,691 patients, death or WHF through day 5 occurred in 12.4
作者:Beth A, Davison;Marco, Metra;Gad, Cotter;Barry M, Massie;John G F, Cleland;Howard C, Dittrich;Christopher, Edwards;Gerasimos, Filippatos;Michael M, Givertz;Barry, Greenberg;Piotr, Ponikowski;Adriaan A, Voors;Christopher M, O'Connor;John R, Teerlink
来源:JACC. Heart failure 2015 年 3卷 5期