Patients with duodenal ulcer have a reduced risk of developing gastric cancer compared to those without. Recently, the prostate stem cell antigen (PSCA) rs2294008 C>T polymorphism was found to be associated with different pathogenesis of duodenal ulcer and gastric cancer developments. However, whether PSCA rs2294008 C>T polymorphism is associated with severity of gastric mucosal atrophy is unclear. We examined the influence of the PSCA rs2294008 C>T polymorphism on susceptibility to H. pylori-related diseases and the relationships between PSCA polymorphism and gastric mucosal atrophy.PSCA rs2294008 C>T polymorphism was assessed in H. pylori-positive Japanese patients (n = 488) with noncardia gastric cancer (n = 193), gastric ulcer (n = 84), duodenal ulcer (n = 61), and atrophic gastritis (n = 150), as well as in H. pylori-negatives (n = 266).Frequency of PSCA rs2294008 C/C genotype in duodenal ulcer was 36.1

作者：Hitomi, Ichikawa；Mitsushige, Sugimoto；Takahiro, Uotani；Shu, Sahara；Mihoko, Yamade；Moriya, Iwaizumi；Takanori, Yamada；Satoshi, Osawa；Ken, Sugimoto；Hiroaki, Miyajima；Yoshio, Yamaoka；Takahisa, Furuta

来源：Helicobacter 2015 年 20卷 2期