Impact of synthetic ghrelin administration for patients with severe body weight reduction more than 1 year after gastrectomy: a phase II clinical trial.-临床诊疗知识库

Impact of synthetic ghrelin administration for patients with severe body weight reduction more than 1 year after gastrectomy: a phase II clinical trial.

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作者：

Shuji, Takiguchi；Yasuhiro, Miyazaki；Tsuyoshi, Takahashi；Yukinori, Kurokawa；Makoto, Yamasaki；Kiyokazu, Nakajima；Hiroshi, Miyata；Hiroshi, Hosoda；Kenji, Kangawa；Masaki, Mori；Yuichiro, Doki

来源：

Surgery today 2016 年 46卷 3期

标签：

Body weight loss Gastric cancer Ghrelin

Ghrelin is mainly secreted from the stomach and plays a role in appetite, weight gain, and the promotion of a positive energy balance. The levels of ghrelin decrease immediately after gastrectomy. We herein investigated the effect of the administration of synthetic ghrelin to treat postoperative severe weight loss in a prospective, one-arm clinical trial to develop new strategies for weight gain.Ten patients (four distal gastrectomy and six total gastrectomy) received ghrelin treatment. Eligibility criteria included patients who underwent gastrectomy more than 1 year previously and 15

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