We investigated the effects of testosterone replacement therapy (TRT) on nocturia and general health among men with hypogonadism and nocturia.From our previous EARTH study population, 64 patients with a clinical diagnosis of nocturia (two or more times per one night) and hypogonadism, comprising the TRT group (n = 31) and controls (n = 33), were included in this analysis. The TRT group was administered 250 mg of testosterone enanthate as an intramuscular injection every 4 weeks for 6 months. All patients responded to the following questionnaires: International Prostatic Symptoms Score (IPSS), Aging Male Symptoms (AMS) score and Short Form-36 health survey at baseline and 6-month visit. These categories were compared based on changes from baseline to the 6-month visit between TRT and control groups.At the 6-month visit, the TRT group had a significant decrease in IPSS question no. 7 and AMS question no. 4, whereas no significant changes were observed in the control group. Additionally, role limitation because of health program, vitality and mental health domains were significantly improved in the TRT group.Six-month TRT may improve nocturia, sleep conditions and quality of life among men with hypogonadism and nocturia.

作者：Kazuyoshi, Shigehara；Hiroyuki, Konaka；Eitetsu, Koh；Koji, Izumi；Yasuhide, Kitagawa；Atsushi, Mizokami；Takao, Nakashima；Masayoshi, Shimamura；Teruaki, Iwamoto；Mikio, Namiki

来源：The aging male : the official journal of the International Society for the Study of the Aging Male 2015 年 18卷 3期