Cerebral microinfarcts (CMI) are important contributors to vascular cognitive impairment. Magnetic resonance imaging diffusion-weighted imaging (DWI) hyperintensities have been suggested to represent acute CMI. We aim to describe a mathematical method for estimating total number of CMI based on the presence of incidental DWI lesions.We reviewed magnetic resonance imaging scans of subjects with cognitive decline, cognitively normal subjects and previously reported subjects with past intracerebral hemorrhage (ICH). Based on temporal and spatial characteristics of DWI lesions, we estimated the annual rate of CMI needed to explain the observed rate of DWI lesion detection in each group. To confirm our estimates, we performed extensive sampling for CMI in the brain of a deceased subject with past lobar ICH who found to have a DWI lesion during life.Clinically silent DWI lesions were present in 13 of 343 (3.8

作者：Eitan, Auriel；M Brandon, Westover；Matt T, Bianchi；Yael, Reijmer；Sergi, Martinez-Ramirez；Jun, Ni；Ellis, Van Etten；Matthew P, Frosch；Panagiotis, Fotiadis；Kris, Schwab；Anastasia, Vashkevich；Grégoire, Boulouis；Alayna P, Younger；Keith A, Johnson；Reisa A, Sperling；Trey, Hedden；M Edip, Gurol；Anand, Viswanathan；Steven M, Greenberg

来源：Stroke 2015 年 46卷 8期