Cerebral microbleeds (CMBs) increase future intracerebral hemorrhage (ICH) risk after ischemic stroke (IS) or transient ischemic attack (TIA). However, whether CMB-related ICH risk depends on CMB quantity, CMB location, or antithrombotic agents is unclear. We performed a systematic review and meta-analysis to investigate CMB-related ICH risk, stratifying patients according to the quantity of CMB, the location of CMB, and the type of antithrombotic therapy used.Literature databases were searched for prospective cohorts reporting ICH outcomes in patients with IS or TIA with baseline CMB evaluation. We calculated pooled relative ratios (RRs) for ICH among patients with and without CMBs. Pooled RRs of CMB-related ICH were further calculated in subgroups stratified by CMB quantity, CMB location, and antithrombotic therapy.Among the 10 included studies, the pooled RR of future ICH was 7.73 (95

作者：Dan-Ni, Wang；Xiao-Wen, Hou；Bo-Wen, Yang；Yi, Lin；Jing-Pu, Shi；Ning, Wang

来源：Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2015 年 24卷 12期