A sensitive and reliable method using liquid chromatography tandem mass spectrometry (LC-MS/MS) was established for the simultaneous assay of paeoniflorin and albiflorin in bio-samples of rats after liquid-liquid extraction with ethylacetate. For the first time, the developed method was validated and successfully applied to the pharmacokinetics study of paeoniflorin and albiflorin after oral administration of Total Glucosides Of White Paeony Capsule (TGP). Relative to the intravenous injection, the absolute bio-availabilities of paeoniflorin and albiflorin were 2.8 and 1.7
作者:Fei, Fei;Hailing, Yang;Ying, Peng;Pei, Wang;Shuyao, Wang;Yuqing, Zhao;Jingqiu, Huang;Xiaoyi, Yu;Siqi, Feng;Runbin, Sun;Na, Yang;Hongbo, Wang;Jiye, Aa;Guangji, Wang
来源:Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2016 年 1022卷