Tenofovir disoproxil fumarate (TDF) is widely used in the treatment or prevention of HIV and hepatitis B infection. TDF may cause renal tubulopathy in a small proportion of recipients. We aimed to study the risk factors for developing severe renal tubulopathy.We conducted an observational cohort study with retrospective identification of cases of treatment-limiting tubulopathy during TDF exposure. We used multivariate Poisson regression analysis to identify risk factors for tubulopathy, and mixed effects models to analyse adjusted estimated glomerular filtration rate (eGFR) slopes.Between October 2002 and June 2013, 60 (0.4
作者:L, Hamzah;S, Jose;J W, Booth;A, Hegazi;M, Rayment;A, Bailey;D I, Williams;B M, Hendry;P, Hay;R, Jones;J B, Levy;D R, Chadwick;M, Johnson;C A, Sabin;F A, Post
来源:The Journal of infection 2017 年 74卷 5期