Autoimmune thyroid disease (AITD) is highly prevalent. Although AITD is less common in males, it is unclear whether estradiol (E2) combined with total testosterone (T) contributes to the prevalence of AITD. This study evaluated the association between the E2/T ratio and the prevalence of AITD in males.The data were obtained from a cross-sectional population-based study, the SPECT-China study, 2014-2015. A total of 4109 males ≥18 years of age were enrolled in this study. Participants underwent several checkups, which included assays of serum E2, T, thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) levels, as well as thyroid ultrasonography (US). AITD was defined based on the presence of TPOAb and TgAb levels, and the presence of thyroid US findings.Overall, the prevalence of positivity for TPOAb and/or TgAb (TPO/TgAb[+]) was 11.02

作者：Yi, Chen；Yingchao, Chen；Fangzhen, Xia；Ningjian, Wang；Chi, Chen；Xiaomin, Nie；Qin, Li；Bing, Han；Hualing, Zhai；Boren, Jiang；Zhoujun, Shen；Yingli, Lu

来源：Thyroid : official journal of the American Thyroid Association 2017 年 27卷 7期