Cytochrome P450 2E1 (CYP2E1) may be a key pathway in generating oxidative stress,nitrosative stress,lipid peroxidation,and causing alcoholic liver injury by various hepatotoxins.It was found that CYP2E1 induction and liver injury occur with co-administration of ethanol and hepatotoxins.CYP2E1 inducers including alcohol and pyrazole could potentiate the hepatotoxicity caused by FAS antibody or LPS,suggesting that overexpression of CYP2E1 might contribute to the synergy and susceptibility of the liver to FAS/LPS-induced liver injury.Thus,CYP2E1 and its polymorphism have important role in liver injury caused by ethanol and are also associated with nonalcoholic steatohepatitis (NASH).Ethanol ingestion and toxin administration drive more CYP2E1 induction contributing to the more severe liver injury.Potential mechanisms involved in the potentiated toxicity include elevated oxidative stress,nitrosative stress,lipid peroxidation,apoptosis,hypoxia,TNF-α production,decreased level of antioxidants and activation of M

作者：王晓东；Arthur I. Cederbaum

来源：第三军医大学学报 2016 年 38卷 14期