Objective: To confirm the value of GnRH antagonist (GnRHant) cetrorelix in preventing the occurrence of premature LH surges and compare a multiple dose and a single dose GnRHant protocols for the COS of IVF/ICSI patients with a short GnRHa protocol.Methods: Single-center randomized, prospective, controlled study was conducted in our study. Ninety infertile women who underwent ovarian stimulation for IVF-ET were selected. Multiple dose of 0.25 mg (Group I) and single dose of 3 mg (Group Ⅱ)of cetrorelix (60 patients) was administered in the late follicular phase. A depot preparation of triptorelin (Decapeptyl) was chosen as a control agent (30 patients) (Group Ⅲ). Ovarian stimulation was conducted with FSH.Results: No premature LH surge occurred after cetrorelix administration. The mean numbers of mature oocytes obtained from patients were (13.47 7.60), (18.66 8.37) and (15.77 10.78) in Groups Ⅰ,Ⅱ and Ⅲ, respectively, showing no statistical difference. The fertilization rates were (78.97 18.11)

来源：生殖医学杂志 2009 年 18卷 z2期