Objective To study the change of plasma and cerebrospinal fluid (CSF) insulin levels and the relationship to intellectual level in patients with multi infarct dementia (MID).Methods The concentration of insulin in plasma and CSF was determined by RIAs in 55 patients with MID. 72 patients with cerebral infarction(CI) and 32 normal subjects were used as controls. Mini mental state examination (MMSE) was used to examine the intellectual level of patients, with DSM IV diagnosis standard and Hachinski Ischemia Score as references. Results The patients in MID had significantly higher plasma insulin level than that in normal controls ( P < 0.01 ), but lower CSF insulin and reduced CSF to plasma insulin ratio (P< 0.01). There was a positively correlated between CSF to plasma insulin ratio and MMSE score for MID as a whole. The patients in CI acute phase group had a higher plasma insulin levels than that in normal controls ( P < 0.05 ) , but CSF to plasma insulin ratio differed statistically from either MID acute ep

作者：周红杰；王景周；高东；张莉莉；李敏

来源：中国临床康复 2002 年 6卷 17期