Objective Neurodegenerative diseases,such as ischemia,traumatic injury,Alzheimer's disease,and Parkinson's disease are characterized by neuronal loss and dysfunction.It is known that glutamate-induced toxicity plays an important role in neurodegenerative diseases.Glutamate toxicity seems to be mediated by excessive influx of Ca2+ into neuronal cells through activation of N-methyl-D-aspartate (NMDA) receptor.To search for potential NMDA receptor inhibitors in traditional Chinese medicine.Methods A series of computer methods including drug-likeness evaluation,ADMET tests as well as molecular docking have been used.Results 1,5-O-dicaffeoyl-quinic acid was identified as NMDA receptor inhibitor by virtual screening.Its neuroprotective activity was further confirmed by in vitro test.1,5-O-dicaffeoyl-quinic acid showed strong neuroprotection against NMDA-induced cell injury.Conclusion 1,5-O-Dicaffeoyl-quinic acid may be regarded as a potential NMDA receptor inhibitor for the prevention and treatment of neurodegene

来源：中草药（英文版） 2016 年 8卷 4期