Osteosarcoma is the most common primary cancer derived from bone tissues, which is frequently found in adolescents and children. The extensive application of the comprehensive limb salvage treatment reduces the amputation rate significantly, and the five-year survival rate is higher. But the prognosis of chemotherapy-resistant patients is still poor. It is very important to improve the prognosis of osteosarcoma by clarifying the pathogenesis of drug resistance. In this paper, we review the mechanism of osteosarcoma chemoresistance, including the non-coding RNA disorders, gene, DNA repair, cancer stem cells, autophagy and tumor microenvironment ect. We also summarize the deficiencies in the current studies about osteosarcoma chemoresistance and hope to improve osteosarcoma chemotherapy sensitivity.

作者：陈金泉；张世权

来源：中国骨与关节杂志 2017 年 6卷 12期