Objective Massive osteolysis is a rare disease characterized by progressive resorption of bones. This study aims to investigate the diagnosis and treatment of massive osteolysis, and to provide references for clinical diagnosis and therapy. Methods A typical case was reported. Etiology, clinical manifestations, imaging performance, pathology, diagnosis as well as therapy were summarized. Results Before the surgery, this patient was treated with diphosphate, calcium and vitamin D until osteolysis stopped and ossification occurred. No recurrence was observed 5 years postoperatively. Conclusions The etiology of massive osteolysis remains obscure. Traumatic history before its onset may be of significance. Massive osteolysis is characterized by an aggressive bone dissolution, whose clinical manifestations are non-specific. Malignancy signs appear in CT or MRI images, which may lead to missed diagnosis or misdiagnosis because of its contradictions to clinical manifestations and pathology. MRI enhanced imaging hel

作者：陈金泉；张世权；关弘；朱智祥；李伟；谭纪锋

来源：中国骨与关节杂志 2018 年 7卷 3期