BACKGROUND: Because of the limitation of technique, there are few researches on regulating function of central hypothalamus by metabolism, especially the researches on real-time function.OBJECTIVE: To evaluate the response of hypothalamus to oral glucose tolerance test (OGTT) in different body-weighted subjects by using functional magnetic resonance imaging (fMRI) so as to investigate the relationship between the sensitivity of hypothalamus in glycoregulation and disturbance of carbohydrate metabolism.DESIGN: Paired design.SETTING: Department of Radiology and Beijing Geriatrics Institute, Beijing Hospital, National Public Health Bureau.PARTICIPANTS: A total of twenty healthy volunteers were selected from Beijing Geriatrics Institute,National Public Health Bureau, including 10 subjects with obesity (5 males and 5 females; body mass ＞28.0 kg/m2) and 10 subjects with normal body mass (5 males and 5 females; body mass from 18.5 to 23.9 kg/m2). All subjects gave written informed consent before participating in

来源：中国神经再生研究（英文版） 2007 年 2卷 9期