OBJECTIVE 1H-NMR-based metabolomics approach was conducted to holistically explore the effect and mechanisms of Cydonia oblanga Mill flavonoids(COMF)on high-fat diet induced Atherosclerosis (AS) apoE-/- mice. METHODS AS model was established on the apolipoprotein e knockout mice by high-fat diet. The ApoE-/- mice were split into 6 groups including control group, AS model group,COMF High dose(COMF-H)group,COMF medium dose(COMF-M)group,COMF Low dose (COMF-L) group and Simvastatin group as the positive control group. Serum samples from all groups were analyzed by 1H-NMR technology and the OPLS-DA was conducted to distinguish the metabolic phenotypes. RESULTS Compared to the control group, serum levels of cholesterol, VLDL, leucine, isoleucine, valine, blood lipid, citrulline, methylamine, glucose, glycine, glycerol, myo-inositol, fructose, phenylalanine, unsaturated lipid, urea and other metabolites content significantly increased, while HDL, lactate, alanine, glutamate, glutamine, pyruvate, carnitine, citrate

来源：中国药理学与毒理学杂志 2018 年 32卷 4期