Background::Resting heart rate (RHR) is considered as a strong predictor of total mortality and hospitalization due to heart failure in hypertension patients. Bisoprolol fumarate, a second-generation beta-adrenoreceptor blockers (β-blocker) is commonly prescribed drug to manage hypertension. The present study was to retrospectively evaluate changes in the average RHR and its association with cardiovascular outcomes in bisoprolol-treated coronary artery disease (CAD) patients from the CAD treated with bisoprolol (BISO-CAD) study who had comorbid hypertension.Methods::We performed ad-hoc analysis for hypertension sub-group of the BISO-CAD study ( n = 866), which was a phase IV, multination, multi-center, single-arm, observational study carried out from October 2011 to July 2015 across China, South Korea, and Vietnam. Multivariate regression analysis was used to identify factors associated with incidence of composite cardiac clinical outcome (CCCO), the results were presented as adjusted odds ratio

作者：Chen Yun-Dai；Yang Xin-Chun；Nguyen Pham Vinh；Huang Shi-An；Fu Guo-Sheng；Chen Xiao-Ping；Quang Truong Binh；Yang Yu；Liu Shao-Wen；Ma Tian-Rong；Kim Dong-Soo；Kim Tae-hoon

来源：中华医学杂志英文版 2020 年 133卷 10期