Type 1 diabetes induced by immune checkpoint inhibitors-临床诊疗知识库

Type 1 diabetes induced by immune checkpoint inhibitors

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作者：

Zhang Rui；Cai Xiao-Ling；Liu Liu；Han Xue-Yao；Ji Li-Nong

来源：

中华医学杂志英文版 2020 年 133卷 21期

标签：

Programmed cell death-1 Type 1 diabetes Immune checkpoint inhibitors Programmed cell death-1 Type 1 diabetes Immune checkpoint inhibitors

With the increasing use of immune checkpoint inhibitors (ICI) including anti-cytotoxic T lymphocyte associated antigen-4 (CTLA-4) and anti-programmed cell death-1 (PD-1) in cancers, ICI-induced type 1 diabetes has been reported throughout the world. In this review, we aim to summarize the characteristics of this disease and discuss the mechanism of it. As an immune-related adverse event, type 1 diabetes developed after the administration of anti-PD-1 or anti-PD-ligand 1 (PD-L1) in the combination with or without anti-CTLA-4. It usually presented with acute onset, and 62.1

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