Background::Endoscopic bariatric therapies can help address widening management gaps in obesity. Their ability to facilitate weight loss is largely tied to influences on appetite through perturbations of gastric emptying and accommodation. As these tools gain traction in obesity therapy, their physiologic underpinnings require exploration, which may enhance efficacy, tolerance, and patient-tailored care.Methods::We prospectively assessed consecutive subjects with fluid-filled intragastric balloons (IGBs) ( n = 18) placed between October 2016 and June 2017 or underwent endoscopic sleeve gastroplasty (ESG) ( n = 23) from March 2018 to June 2018. Patients underwent physiologic appraisal at 3 months with 13C-spirulina-based gastric emptying breath test to determine time to half emptying (T50), as well as maximum tolerated volume (MTV) of a standard nutrient drink test. Changes in T50 and MTV at 3 months were compared with percent total body weight loss (

作者：Rapaka Babusai；Maselli Daniel B.；Lopez-Nava Gontrand；Bautista-Casta?o Inmaculada；Matar Reem；Jaruvongvanich Veeravich；Vargas Eric J.；Storm Andrew C.；Acosta Andres；Abu Dayyeh Barham K.

来源：中华医学杂志英文版 2022 年 135卷 10期