Background::Many nutritional supplements and pharmacological agents have been reported to show preventive effects on colorectal adenoma and colorectal cancer (CRC). We performed a network meta-analysis to summarize such evidence and assess the efficacy and safety of these agents.Methods::We searched PubMed, Embase, and the Cochrane Library for studies published in English until October 31, 2021 that fit our inclusion criteria. We performed a systematic review and network meta-analysis to assess the comparative efficacy and safety of candidate agents (low-dose aspirin [Asp], high-dose Asp, cyclooxygenase-2 inhibitors [coxibs], calcium, vitamin D, folic acid, ursodeoxycholic acid [UDCA], estrogen, and progesterone, alone or in combination) for preventing colorectal adenoma and CRC. Cochrane risk-of-bias assessment tool was employed to evaluate the quality of each included study.Results::Thirty-two randomized controlled trials (278,694 participants) comparing 13 different interventions were included. Coxibs sign

作者：Ma Ye；You Wen；Cao Yang；He Xuxia；Wang Jing；Zhang Yuelun；Li Ji；Li Jingnan

来源：中华医学杂志英文版 2023 年 136卷 7期