Cantharidin is an agent isolated from Mylabris phalerata Pall 斑蝥 Given in a dose of 1.25-2 mg intraperitoneally or orally it exhibited an inhibitory action on reticulo-cell sarcoma and ascites hepatoma in mice inoculated with 2 million tumor cells. Intraperitoncal injections of 0.4-1.0 mg/kg of this drug showed no marked influence on the concomitant ijw munity and GVH (graft versus host) reaction in 'nice. Intragastric or intraperitoneal injection of 3H_cantharidin led to a high level of radioac- tivity in the bile, kidney, liver, stomach and tumor cells of ascitic hepatoma-bearing mice; within 24 hours after administration radioactivi- ty excreted in the urine and feces was about 580/o. In patients with liver carcinoma canthari- din also had some palliative therapeutic effect.
作者:Chen Ruiting;Hua Ze;Yang Jinlong;Han Jiaxian;Zhang Suyin;Lü Feili;Xu Bin
来源:CHINESE MEDICAL JOURNAL 1980 年 93卷 3期