S100B and its scavenger, soluble receptor for advanced glycation end products (sRAGE), participate in various acute and chronic brain disorders. However, their impact on hemorrhage-prone small vessel disease represented by cerebral microbleeds (CMBs) is unclear. The purpose of this study was to investigate the relationship of CMBs with plasma S100B and sRAGE.A cohort of 147 consecutive patients with first-ever acute lacunar stroke was prospectively enrolled. We collected demographic, clinical, and laboratory data, including plasma levels of S100B and sRAGE, and presence and number of CMBs using susceptibility-weighted imaging (SWI). Associations between plasma S100B, sRAGE levels and the presence, number, and location of CMBs were determined.CMBs were present in 58 patients (39.5

作者：Lulu, Xiao；Wen, Sun；Wenya, Lan；Yunyun, Xiong；Zuowei, Duan；Zongjun, Zhang；Wenping, Fan；Lili, Xu；Xia, Xie；Nan, Ma；Ruidong, Ye；Gelin, Xu；Xinfeng, Liu；Wusheng, Zhu

来源：Journal of the neurological sciences 2014 年 340卷 1-2期