To review the research and clinical status of multifocal osteosarcoma (MFOS), and discuss its origin.Osteosarcoma (OS) is one of the most common malignant bone tumors in adolescents, with metastasis in early stage and the five year survival is only about 60％.MFOS was reported by Silverman firstly in 1936, which was rare but invasive.There have been only 300 cases reported in literature till now.MFOS is characterized by the presence of tumor lesions in osseous sites without pulmonary metastasis.The MFOS patients present rapid progress, poor reaction with chemo-drugs and with a very terrible outcome.However, it has low incidence.With clinical and economic progress, the detection rate of MFOS has been promoted in recent years.Along with the development of novel research methods, deeper understanding makes the treatment much more individualized.

作者：张浩强；鲁亚杰；李明辉；李旭升；甄平；王臻

来源：中国骨与关节杂志 2019 年 8卷 1期